Specific clone inhibition of identical cells by Invasivol
Sparsely distributed identical cells can grow separated from identical cells and form clones. This process is inhibited by Invasivol. If the same cells are densely packed locally, their growth is not inhibited by Invasivol. They grow, but not as clones. The many normal cells in the abdominal cavity of mice transplanted with single cells from mouse cancer, however, do not inactivate the effect of Invasivol on the cancer cells. Therefore, the effect of specific clone inhibitors on special identical cells depends not only on their individual qualities, but on the local density of the identical cells.
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Cloning
Cloning
of all kinds of cells is probably inhibited by Invasivol. The immune
system is
a good illustration of that. The individual cells in the spleen produce
innate
antibodies to millions of possible intruders. If one of these enters
the body,
cells producing antibodies against this intruder, will quickly
begin to multiply as
clones. After a few days these cells are so many that the amount of
antibodies
becomes sufficient for fighting the intruder. Invasivol inhibits
this growth of clones dose dependently.